Association of BRAF V600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers.

doi:10.1089/thy.2015.0378

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Article

Association of BRAF V600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2016

Han Patricia Aragon, Kim Hyun-seok, Cho Soonweng, Fazeli Roghayeh, Najafian Alireza, Khawaja Hunain, McAlexander Melissa, Dy Benzon, Sorensen Meredith, Aronova Anna, Sebo Thomas J, Giordano Thomas J, Fahey Thomas J, Thompson Geoffrey B, Gauger Paul G, Somervell Helina, Bishop Justin A, Eshleman James R, Schneider Eric B, Witwer Kenneth W, Umbricht Christopher B, Zeiger Martha A

Abstract excerpt

BACKGROUND: Studies have demonstrated an association of the BRAF(V600E) mutation and microRNA (miR) expression with aggressive clinicopathologic features in papillary thyroid cancer (PTC). Analysis of BRAF(V600E) mutations with miR expression data may improve perioperative decision making for patients with PTC, specifically in identifying patients harboring central lymph node metastases (CLNM). METHODS: Between...

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PMID: 26950846
DOI: 10.1089/thy.2015.0378
PMCID: PMC4827320

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BRAF

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