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Article

Transgenerational latent early-life associated regulation unites environment and genetics across generations.

Epigenomics - 1 Mar 2016

Lahiri Debomoy K, Maloney Bryan, Bayon Baindu L, Chopra Nipun, White Fletcher A, Greig Nigel H, Nurnberger John I

Abstract excerpt

The origin of idiopathic diseases is still poorly understood. The latent early-life associated regulation (LEARn) model unites environmental exposures and gene expression while providing a mechanistic underpinning for later-occurring disorders. We propose that this process can occur across generations via transgenerational LEARn (tLEARn). In tLEARn, each person is a 'unit' accumulating preclinical or subclinical...

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Identifiers

PMID: 26950428
DOI: 10.2217/epi.15.117
PMCID: PMC4864244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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