Article
The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent.
PloS one - 1 Jan 2016
Osadnik Tadeusz, Strzelczyk Joanna Katarzyna, Reguła Rafał, Bujak Kamil, Fronczek Martyna, Gonera Małgorzata, Gawlita Marcin, Wasilewski Jarosław, Lekston Andrzej, Kurek Anna, Gierlotka Marek, Trzeciak Przemysław, Hawranek Michał, Ostrowska Zofia, Wiczkowski Andrzej, Poloński Lech, Gąsior Mariusz
Abstract excerpt
BACKGROUND: Neointima forming after stent implantation consists of vascular smooth muscle cells (VSMCs) in 90%. Growth factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A play an important role in VSMC proliferation and migration to the tunica intima after arterial wall injury. The aim of this paper was an analysis of functional polymorphisms in genes encoding TGF-β1, PDGFB, EGF, bFGF and VEGF-A in relation to in-stent...
Topics
- Aged
- Coronary Artery Disease
- Coronary Restenosis
- Epidermal Growth Factor
- Female
- Fibroblast Growth Factor 2
- Genetic Predisposition to Disease
- Humans