Article
Expression of a second open reading frame present in the genome of tick-borne encephalitis virus strain Neudoerfl is not detectable in infected cells.
Virus genes - 1 Jun 2016
Černý Jiří, Selinger Martin, Palus Martin, Vavrušková Zuzana, Tykalová Hana, Bell-Sakyi Lesley, Štěrba Ján, Grubhoffer Libor, Růžek Daniel
Abstract excerpt
A short upstream open reading frame (uORF) was recently identified in the 5' untranslated region of some tick-borne encephalitis virus (TBEV) strains. However, it is not known if the peptide encoded by TBEV uORF (TuORF) is expressed in infected cells. Here we show that TuORF forms three phylogenetically separated clades which are typical of European, Siberian, and Far-Eastern TBEV subtypes. Analysis of selection...
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