Article
Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes.
G3 (Bethesda, Md.) - 3 May 2016
Tiosano Dov, Audi Laura, Climer Sharlee, Zhang Weixiong, Templeton Alan R, Fernández-Cancio Monica, Gershoni-Baruch Ruth, Sánchez-Muro José Miguel, El Kholy Mohamed, Hochberg Zèev
Abstract excerpt
The well-documented latitudinal clines of genes affecting human skin color presumably arise from the need for protection from intense ultraviolet radiation (UVR) vs. the need to use UVR for vitamin D synthesis. Sampling 751 subjects from a broad range of latitudes and skin colors, we investigated possible multilocus correlated adaptation of skin color genes with the vitamin D receptor gene (VDR), using a vector...
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