Inferential considerations for low-count RNA-seq transcripts: a case study on the dominant prairie grass Andropogon gerardii.

Abstract excerpt

BACKGROUND: Differential expression (DE) analysis of RNA-seq data still poses inferential challenges, such as handling of transcripts characterized by low expression levels. In this study, we use a plasmode-based approach to assess the relative performance of alternative inferential strategies on RNA-seq transcripts, with special emphasis on transcripts characterized by a small number of read counts, so-called...

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