GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study.

doi:10.1161/CIRCHEARTFAILURE.115.002683

Article

GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study.

Circulation. Heart failure - 1 Mar 2016

Sheppard Richard, Hsich Eileen, Damp Julie, Elkayam Uri, Kealey Angela, Ramani Gautam, Zucker Mark, Alexis Jeffrey D, Horne Benjamin D, Hanley-Yanez Karen, Pisarcik Jessica, Halder Indrani, Fett James D, McNamara Dennis M

Abstract excerpt

BACKGROUND: Black women are at greater risk for peripartum cardiomyopathy (PPCM). The guanine nucleotide-binding proteins β-3 subunit (GNB3) has a polymorphism C825T. The GNB3 TT genotype more prevalent in blacks is associated with poorer outcomes. We evaluated GNB3 genotype and myocardial recovery in PPCM. METHODS AND RESULTS: A total of 97 women with PPCM were enrolled and genotyped for the GNB3 T/C...

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