Article
Impact of centralized evaluation of bone marrow histology in systemic mastocytosis.
European journal of clinical investigation - 1 May 2016
Jawhar Mohamad, Schwaab Juliana, Horny Hans-Peter, Sotlar Karl, Naumann Nicole, Fabarius Alice, Valent Peter, Cross Nicholas C P, Hofmann Wolf-Karsten, Metzgeroth Georgia, Reiter Andreas
Abstract excerpt
BACKGROUND: Bone marrow (BM) histology/immunohistochemistry, KIT D816V mutation analysis and serum tryptase measurements are mandatory tools for diagnosis of systemic mastocytosis (SM). MATERIALS AND METHODS: Within the 'German Registry of Disorders on Eosinophils and Mast Cells', we identified 65 patients with SM who had two consecutive BM biopsies. The first biopsy was evaluated by a local pathologist (LP) and...
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