Article
Increased oxidative stress in pemphigus vulgaris is related to disease activity and HLA-association.
Autoimmunity - 1 Jun 2016
Shah Amit Aakash, Dey-Rao Rama, Seiffert-Sinha Kristina, Sinha Animesh A
Abstract excerpt
Pemphigus vulgaris (PV) is a rare blistering skin disorder characterized by the disadhesion of keratinocytes due to autoantibody attack against epidermal targets including desmoglein (Dsg) 3, Dsg 1 and possibly other adhesion and non-adhesion molecules. The mechanisms leading to immune-mediated pathology in PV are multifactorial and not fully understood. Recently, oxidative stress (antioxidant/oxidant...
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