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B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study.

Immunogenetics - 1 Jun 2024

Khoshnevisan Razieh, Hassanzadeh Shakiba, Klein Christoph, Rohlfs Meino, Grimbacher Bodo, Molavi Newsha, Zamanifar Aryana, Khoshnevisan Ali, Jafari Mahbube, Bagherpour Bahram, Behnam Mahdiyeh, Najafi Somayeh, Sherkat Roya

Abstract excerpt

Hypogammaglobulinemia without B-cells is a subgroup of inborn errors of immunity (IEI) which is characterized by a significant decline in all serum immunoglobulin isotypes, coupled with a pronounced reduction or absence of B-cells. Approximately 80 to 90% of individuals exhibit genetic variations in Bruton's agammaglobulinemia tyrosine kinase (BTK), whereas a minority of cases, around 5-10%, are autosomal...

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PMID: 38683392
DOI: 10.1007/s00251-024-01342-y

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