Article
Clinical, immunological and molecular characteristics of 37 Iranian patients with X-linked agammaglobulinemia.
International archives of allergy and immunology - 1 Jan 2006
Aghamohammadi Asghar, Fiorini Maurilia, Moin Mostafa, Parvaneh Nima, Teimourian Shahram, Yeganeh Mehdi, Goffi Francesca, Kanegane Hirokazu, Amirzargar Ali Akbar, Pourpak Zahra, Rezaei Nima, Salavati Ali, Pouladi Nima, Abdollahzade Sina, Notarangelo Luigi D, Miyawaki Toshio, Plebani Alessandro
Abstract excerpt
BACKGROUND: X-linked agammaglobulinemia (XLA) is a hereditary immunodeficiency characterized by an early onset of recurrent bacterial infections, a profound deficiency of all immunoglobulin isotypes and a markedly reduced number of peripheral B lymphocytes. Eighty-five percent of the patients with this phenotype have mutations in Bruton's tyrosine kinase (BTK) gene. METHODS: To provide an informative outlook of...
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