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Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression

1 Jul 2021

Abstract excerpt

We have established experimental systems to assess the effects of early-life exposures to antibiotics on the intestinal microbiota and gene expression in the brain. This model system is highly relevant to human exposure and may be developed into a preclinical model of neurodevelopmental disorders in which the gut-brain axis is perturbed, leading to organizational effects that permanently alter the structure and...

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PMID: 34355145
DOI: 10.1016/j.isci.2021.102797

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