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New England harbor seal H3N8 influenza virus retains avian-like receptor specificity

18 Feb 2016

Abstract excerpt

An influenza H3N8 virus, carrying mammalian adaptation mutations, was isolated from New England harbor seals in 2011. We sought to assess the risk of its human transmissibility using two complementary approaches. First, we tested the binding of recombinant hemagglutinin (HA) proteins of seal H3N8 and human-adapted H3N2 viruses to respiratory tissues of humans and ferrets. For human tissues, we observed strong...

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PMID: 26888262
DOI: 10.1038/srep21428

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