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Genotype A3 influenza A(H5N1) isolated from fur seals shows high virulence in mammals, but not airborne transmission.

Scientific reports - 24 Dec 2025

Panova Anastasia S, Gudymo Andrey S, Kolosova Natalia P, Danilenko Alexey V, Shadrinova Kiunnei N, Danilchenko Natalia V, Perfilieva Olga N, Moiseeva Anastasia A, Danilenko Elena I, Onkhonova Galina S, Goncharova Natalia I, Svyatchenko Svetlana V, Vasiltsova Natalia N, Egorova Marina L, Marchenko Vasiliy Yu

Abstract excerpt

The global spread of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses has recently extended to include diverse mammalian species, raising new concerns about pandemic risk. In 2023, this clade was first detected in Russian marine mammals during a mass mortality event among northern fur seals in the Far East. Genetic analyses revealed the causative viruses to belong to genotype A3 of European...

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PMID: 41444280
DOI: 10.1038/s41598-025-28032-3
PMCID: PMC12738811

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