Article
DEPTOR promoter genetic variants and insulin resistance in obese children and adolescents.
Pediatric diabetes - 1 Mar 2017
Kovač Jernej, Šutuš Temovski Tamara, Rozmarič Tomaž, Horvat Simon, Beltram Jasmina, Trebušak Podkrajšek Katarina, Battelino Tadej, Kotnik Primož
Abstract excerpt
BACKGROUND: Insulin resistance (IR) is one of the major metabolic complications of obesity in children and adolescents. DEP domain-containing mammalian target of rapamycin interacting protein (DEPTOR) is involved in downstream insulin signaling and DEPTOR's effects are regulated by its level of expression. OBJECTIVES: To analyze promoter region of DEPTOR for genetic variants associated with altered IR in obese...
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