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Take your PIKK: tumour viruses and DNA damage response pathways

11 Sept 2017

Abstract excerpt

Viruses regulate cellular processes to facilitate viral replication. Manipulation of nuclear proteins and pathways by nuclear replicating viruses often causes cellular genome instability that contributes to transformation. The cellular DNA damage response (DDR) safeguards the host to maintain genome integrity, but DNA tumour viruses can manipulate the DDR to promote viral propagation. In this review, we describe...

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PMID: 28893936
DOI: 10.1098/rstb.2016.0269

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