Article
Searching for Classical Brown Fat in Humans: Development of a Novel Human Fetal Brown Stem Cell Model.
Stem cells (Dayton, Ohio) - 1 Jun 2016
Di Franco Alessandra, Guasti Daniele, Squecco Roberta, Mazzanti Benedetta, Rossi Francesca, Idrizaj Eglantina, Gallego-Escuredo José M, Villarroya Francesc, Bani Daniele, Forti Gianni, Vannelli Gabriella Barbara, Luconi Michaela
Abstract excerpt
The potential therapeutic applications of targeting brown adipose tissue open new clinical avenues in fighting against metabolic pathologies. However, due to the limited extension in adult humans of brown depots, which are dramatically reduced after birth, solid cell models to study human brown adipogenesis and its regulatory factors in pathophysiology are urgently needed. Here, we generated a novel human model...
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