Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations.

doi:10.1167/iovs.12-10219

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Article

Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations.

Investigative ophthalmology & visual science - 25 Sept 2012

Nakata Isao, Yamashiro Kenji, Akagi-Kurashige Yumiko, Miyake Masahiro, Kumagai Kyoko, Tsujikawa Akitaka, Liu Ke, Chen Li Jia, Liu David T L, Lai Timothy Y Y, Sakurada Yoichi, Yoneyama Seigo, Cheng Ching-Yu, Cackett Peter, Yeo Ian Y, Tay Wan Ting, Cornes Belinda K, Vithana Eranga N, Aung Tin, Matsuo Keitaro, Matsuda Fumihiko, Wong Tien-Yin, Iijima Hiroyuki, Pang Chi Pui, Yoshimura Nagahisa

Abstract excerpt

PURPOSE: To evaluate the association of genetic variants at chromosomes 8p21 and 4q12 with the risk of developing AMD and its two main subtypes, choroidal neovascular membrane (CNV) and polypoidal choroidal vasculopathy (PCV), in Asian populations. METHODS: The study population comprised 2360 patients with neovascular AMD (1013 typical AMD-CNV and 1282 PCV), and 3598 controls from four independent cohorts, two of...

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PMID: 22930721
DOI: 10.1167/iovs.12-10219

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IGFBP7
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