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Article

Roles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization

5 Feb 2016

Abstract excerpt

The steroid hormones 17β-estradiol and progesterone are critical regulators of endometrial stromal cell differentiation, known as decidualization, which is a prerequisite for successful establishment of pregnancy. The present study using primary human endometrial stromal cells (HESCs) addressed the role of estrogen receptor-α (ESR1) in decidualization. Knockdown of ESR1 transcripts by RNA interference led to a...

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PMID: 26849466
DOI: 10.1210/me.2015-1274

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