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Article

Disease and Polygenic Architecture: Avoid Trio Design and Appropriately Account for Unscreened Control Subjects for Common Disease.

American journal of human genetics - 4 Feb 2016

Peyrot Wouter J, Boomsma Dorret I, Penninx Brenda W J H, Wray Naomi R

Abstract excerpt

Genome-wide association studies (GWASs) are an optimal design for discovery of disease risk loci for diseases whose underlying genetic architecture includes many common causal loci of small effect (a polygenic architecture). We consider two designs that deserve careful consideration if the true underlying genetic architecture of the trait is polygenic: parent-offspring trios and unscreened control subjects. We...

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Identifiers

PMID: 26849113
DOI: 10.1016/j.ajhg.2015.12.017
PMCID: PMC4746372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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