Article
Gene integrated set profile analysis: a context-based approach for inferring biological endpoints.
Nucleic acids research - 20 Apr 2016
Kowalski Jeanne, Dwivedi Bhakti, Newman Scott, Switchenko Jeffery M, Pauly Rini, Gutman David A, Arora Jyoti, Gandhi Khanjan, Ainslie Kylie, Doho Gregory, Qin Zhaohui, Moreno Carlos S, Rossi Michael R, Vertino Paula M, Lonial Sagar, Bernal-Mizrachi Leon, Boise Lawrence H
Abstract excerpt
The identification of genes with specific patterns of change (e.g. down-regulated and methylated) as phenotype drivers or samples with similar profiles for a given gene set as drivers of clinical outcome, requires the integration of several genomic data types for which an 'integrate by intersection' (IBI) approach is often applied. In this approach, results from separate analyses of each data type are...
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