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Article

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

28 Jan 2016

Abstract excerpt

Rhabdoid tumours (RTs) are highly aggressive tumours of infancy, frequently localized in the central nervous system (CNS) where they are termed atypical teratoid/rhabdoid tumours (AT/RTs) and characterized by bi-allelic inactivation of the SMARCB1 tumour suppressor gene. In this study, by temporal control of tamoxifen injection in Smarcb1(flox/flox);Rosa26-Cre(ERT2) mice, we explore the phenotypes associated with...

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PMID: 26818002
DOI: 10.1038/ncomms10421

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