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Article

Prostaglandin E2 as a Regulator of Germ Cells during Ovarian Development

15 Jul 2009

Abstract excerpt

CONTEXT: The formation of primordial follicles occurs during fetal life yet is critical to the determination of adult female fertility. Prior to this stage, germ cells proliferate, enter meiosis, and associate with somatic cells. Growth and survival factors implicated in these processes include activin A (INHBA), the neurotrophins BDNF and NT4 (NTF5), and MCL1. The prostaglandins have pleiotrophic roles in...

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PMID: 19602557
DOI: 10.1210/jc.2009-0755

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