Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma

25 Jan 2016

Abstract excerpt

Targeting and inhibiting DNA repair pathways is a powerful strategy of controlling malignant growth. One such strategy includes the inhibition of PARP1, a central element in the intracellular DNA damage response. To determine and visualize the expression and intercellular distribution of PARP1 in vivo, and to monitor the pharmacokinetics of PARP1 targeted therapeutics, fluorescent small probes were developed. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Effects of Radiation Exposure
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26808835
DOI: 10.1371/journal.pone.0147752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell CarcinomaPMID 26808835Read ↗

Molecular Imaging of PARPSemantic proximity Read ↗

Single cell resolution in vivo imaging of DNA damage following PARP inhibition.Semantic proximity Read ↗

Molecular Imaging: PARP-1 and BeyondSemantic proximity Read ↗

Advancements in PARP1 Targeted Nuclear Imaging and Theranostic ProbesSemantic proximity Read ↗

PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor ResponseSemantic proximity Read ↗

Image-based Morphological Profiling Reveals Signatures of Radiation ExposureSemantic proximity Read ↗

PARP-1–Targeted Auger Emitters Display High-LET Cytotoxic Properties In Vitro but Show Limited Therapeutic Utility in Solid Tumor Models of Human NeuroblastomaSemantic proximity Read ↗

PARP1-targeted fluorescence molecular endoscopy as novel tool for early detection of esophageal dysplasia and adenocarcinomaSemantic proximity Read ↗

Quantification of single-strand DNA lesions caused by the topoisomerase II poison etoposide using single DNA molecule imagingSemantic proximity Read ↗

In vivo visualization of PARP inhibitor pharmacodynamicsSemantic proximity Read ↗

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation responseSemantic proximity Read ↗

Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.