Article
Clinical evaluation of panel testing by next-generation sequencing (NGS) for gene mutations in myeloid neoplasms.
Diagnostic pathology - 22 Jan 2016
Au Chun Hang, Wa Anna, Ho Dona N, Chan Tsun Leung, Ma Edmond S K
Abstract excerpt
BACKGROUND: Genomic techniques in recent years have allowed the identification of many mutated genes important in the pathogenesis of acute myeloid leukemia (AML). Together with cytogenetic aberrations, these gene mutations are powerful prognostic markers in AML and can be used to guide patient management, for example selection of optimal post-remission therapy. The mutated genes also hold promise as therapeutic...
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