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Article

Clinical performance and utility of a comprehensive next-generation sequencing DNA panel for the simultaneous analysis of variants, TMB and MSI for myeloid neoplasms.

PloS one - 1 Jan 2020

Sahajpal Nikhil Shri, Mondal Ashis K, Ananth Sudha, Njau Allan, Ahluwalia Pankaj, Jones Kimya, Ahluwalia Meenakshi, Okechukwu Nwogbo, Savage Natasha M, Kota Vamsi, Rojiani Amyn M, Kolhe Ravindra

Abstract excerpt

The extensively employed limited-gene coverage NGS panels lead to clinically inadequate molecular profiling of myeloid neoplasms. The aim of the present investigation was to assess performance and clinical utility of a comprehensive DNA panel for myeloid neoplasms. Sixty-one previously well characterized samples were sequenced using TSO500 library preparation kit on NextSeq550 platform. Variants with a VAF ≥ 5%...

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Identifiers

PMID: 33075099
DOI: 10.1371/journal.pone.0240976
PMCID: PMC7571681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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