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Article

Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction.

Journal of translational medicine - 20 Jan 2016

Raphael Roseanne, Purushotham Diana, Gastonguay Courtney, Chesnik Marla A, Kwok Wai-Meng, Wu Hsiang-En, Shah Sanjiv J, Mirza Shama P, Strande Jennifer L

Abstract excerpt

BACKGROUND: Heart failure with ejection fraction (HFpEF) is a syndrome resulting from several co-morbidities in which specific mediators are unknown. The platelet proteome responds to disease processes. We hypothesize that the platelet proteome will change composition in patients with HFpEF and may uncover mediators of the syndrome. METHODS AND RESULTS: Proteomic changes were assessed in platelets from...

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Identifiers

PMID: 26792056
DOI: 10.1186/s12967-016-0774-3
PMCID: PMC4719542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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