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UBE4B promotes gastric cancer proliferation and metastasis by mediating FAT4 ubiquitination and degradation

23 Jul 2025

Abstract excerpt

The ubiquitin‒proteasome system (UPS), an intracellular protein degradation pathway, plays an important role in regulating tumorigenesis and development. Ubiquitination factor E4B (UBE4B/UFD2) has been shown to be associated with the development of several cancers. The aim of this study was to reveal the functional significance of UBE4B in gastric cancer (GC) development and its important mechanism....

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PMID: 40701960
DOI: 10.1038/s41419-025-07794-8

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