Microarray and whole-exome sequencing analysis of familial Behçet's disease patients.

doi:10.1038/srep19456

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Microarray and whole-exome sequencing analysis of familial Behçet's disease patients.

Scientific reports - 20 Jan 2016

Okuzaki Daisuke, Yoshizaki Kazuyuki, Tanaka Toshio, Hirano Toru, Fukushima Kohshiro, Washio Takanori, Nojima Hiroshi

Abstract excerpt

Behçet's disease (BD), a chronic systemic inflammatory disorder, is characterized by recurrent oral and genital mucous ulcers, uveitis, and skin lesions. We performed DNA microarray analysis of peripheral blood mononuclear cell (PBMC) mRNA from 41 Japanese BD patients and revealed elevated levels of interleukin (IL) 23 receptor (IL23R) mRNA in many BD patients. DNA sequencing around a SNV (Rs12119179) tightly...

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PMID: 26785681
DOI: 10.1038/srep19456
PMCID: PMC4726226

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