Article
The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects.
The Journal of allergy and clinical immunology - 1 Jan 2016
Grimbacher Bodo, Warnatz Klaus, Yong Patrick F K, Korganow Anne-Sophie, Peter Hans-Hartmut
Abstract excerpt
Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune system and represent 2 sides of the same coin. Multiple single-gene defects have been identified, resulting in rare diseases with features of both autoimmunity and immunodeficiency. On the other hand, more common autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, show a polygenic inheritance pattern....
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