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Article

Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects.

PLoS genetics - 1 Nov 2011

Grossman Tamar R, Gamliel Amir, Wessells Robert J, Taghli-Lamallem Ouarda, Jepsen Kristen, Ocorr Karen, Korenberg Julie R, Peterson Kirk L, Rosenfeld Michael G, Bodmer Rolf, Bier Ethan

Abstract excerpt

A significant current challenge in human genetics is the identification of interacting genetic loci mediating complex polygenic disorders. One of the best characterized polygenic diseases is Down syndrome (DS), which results from an extra copy of part or all of chromosome 21. A short interval nea...

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Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Heart Defects, Congenital

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Source

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Identifiers

PMID: 22072978
DOI: 10.1371/journal.pgen.1002344
PMCID: PMC3207880

Genes

DSCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22072978-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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