Article
Effect of TH2 cytokines and interferon gamma on beat frequency of human respiratory cilia.
Pediatric research - 1 May 2016
Grosse-Onnebrink Joerg, Werner Claudius, Loges Niki Tomas, Hörmann Karl, Blum Andreas, Schmidt Rene, Olbrich Heike, Omran Heymut
Abstract excerpt
BACKGROUND: In asthmatic airways secondary ciliary dyskinesia contributes to impaired mucociliary clearance. To investigate underlying mechanisms, we studied the effects of cytokines associated with asthma phenotype on the ciliary beat frequency (CBF) in a cell culture model of ciliated human respiratory epithelial cells. METHODS: Nasal respiratory epithelial cells of 21 patients were used to prepare...
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