Article
Changes in pathogenicity and immunogenicity of Mycoplasma mycoides subsp. mycoides strains revealed by comparative genomics analysis.
Scientific reports - 11 Jan 2016
Li Yuan, Wang Yang, Wang Rui, Zhu Yongqiang, Liu Suli, Wang Qi, Shao Jiari, Chen Ying, Gao Liping, Zhou Changping, Liu Henggui, Wang Xiumei, Zheng Huajun, Xin Jiuqing
Abstract excerpt
Mycoplasma mycoides subsp. mycoides is the causative agent of contagious bovine pleuropneumonia. A pathogenic strain BEN-1 was isolated from bovine lung and underwent continuous passages in rabbits for 468 generations. During this process, the strain's strong virulence became weak and, gradually, it lost the ability to confer protective immunity in cattle but developed virulence in rabbits. In order to gain...
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