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Article

JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis

11 Jan 2016

Abstract excerpt

Entire or partial deletions of the male-specific Y chromosome are associated with tumorigenesis, but whether any male-specific genes located on this chromosome play a tumor-suppressive role is unknown. Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness and suppresses the...

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PMID: 26747897
DOI: 10.1158/0008-5472.can-15-0906

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