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Article

Squamous Cell Carcinoma "Transformation" Concurrent with Secondary T790M Mutation in Resistant EGFR-Mutated Adenocarcinomas.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2016

Jukna Agita, Montanari Gloria, Mengoli Maria Cecilia, Cavazza Alberto, Covi Marisa, Barbieri Fausto, Bertolini Federica, Rossi Giulio

Abstract excerpt

The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26746366
DOI: 10.1016/j.jtho.2015.12.096

Genes

EGFR

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