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Characterization of a relaxase belonging to the MOBT family, a widespread family in Firmicutes mediating the transfer of ICEs

3 May 2019

Abstract excerpt

Conjugative spread of antibiotic resistance and virulence genes in bacteria constitutes an important threat to public health. Beyond the well-known conjugative plasmids, recent genome analyses have shown that integrative and conjugative elements (ICEs) are the most widespread conjugative elements, even if their transfer mechanism has been little studied until now. The initiator of conjugation is the relaxase, a...

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PMID: 31073337
DOI: 10.1186/s13100-019-0160-9

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Research trail→

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Characterization of a relaxase belonging to the MOBT family, a widespread family in Firmicutes mediating the transfer of ICEsPMID 31073337Read ↗

Mobilization of IMEs Integrated in the oriT of ICEs Involves Their Own Relaxase Belonging to the Rep-Trans Family of ProteinsSemantic proximity Read ↗

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Streptococcal group B integrative and mobilizable element IMESag-rpsI encodes a functional relaxase involved in its transfer.Semantic proximity Read ↗

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Comparative analysis of MOB <sub>Q4</sub> plasmids demonstrates that MOB <sub>Q</sub> is a <i>cis</i> -acting-enriched relaxase protein familySemantic proximity Read ↗

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