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Sporadic, Global Linkage Disequilibrium Between Unlinked Segregating Sites.

Genetics - 1 Feb 2016

Skelly Daniel A, Magwene Paul M, Stone Eric A

Abstract excerpt

Demographic, genetic, or stochastic factors can lead to perfect linkage disequilibrium (LD) between alleles at two loci without respect to the extent of their physical distance, a phenomenon that Lawrence et al. (2005a) refer to as "genetic indistinguishability." This phenomenon can complicate genotype-phenotype association testing by hindering the ability to localize causal alleles, but has not been thoroughly...

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PMID: 26715671
DOI: 10.1534/genetics.115.177816
PMCID: PMC4788226

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