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Article

Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2016

Köstlin Natascha, Hofstädter Kathrin, Ostermeir Anna-Lena, Spring Bärbel, Leiber Anja, Haen Susanne, Abele Harald, Bauer Peter, Pollheimer Jürgen, Hartl Dominik, Poets Christian F, Gille Christian

Abstract excerpt

Tolerance induction toward the semiallogeneic fetus is crucial to enable a successful pregnancy; its failure is associated with abortion or preterm delivery. Skewing T cell differentiation toward a Th2-dominated phenotype seems to be pivotal in maternal immune adaption, yet underlying mechanisms are incompletely understood. Myeloid-derived suppressor cells (MDSCs) are innate immune cells that mediate T cell...

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Abortion, Spontaneous
Flow Cytometry
Granulocytes
Immune Tolerance
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26712947
DOI: 10.4049/jimmunol.1500340

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