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Article

Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601.

Cell research - 1 Aug 2011

Zhong Yi, Chang Xiao, Cao Xing-Jun, Zhang Yan, Zheng Huajun, Zhu Yongzhang, Cai Chengsong, Cui Zelin, Zhang Yunyi, Li Yuan-Yuan, Jiang Xiu-Gao, Zhao Guo-Ping, Wang Shengyue, Li Yixue, Zeng Rong, Li Xuan, Guo Xiao-Kui

Abstract excerpt

The virulence-attenuated Leptospira interrogans serovar Lai strain IPAV was derived by prolonged laboratory passage from a highly virulent ancestral strain isolated in China. We studied the genetic variations of IPAV that render it avirulent via comparative analysis against the pathogenic L. interrogans serovar Lai strain 56601. The complete genome sequence of the IPAV strain was determined and used to compare...

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Identifiers

PMID: 21423275
DOI: 10.1038/cr.2011.46
PMCID: PMC3193473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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