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Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira

2 Feb 2016

Abstract excerpt

Leptospirosis, caused by pathogenic Leptospira spp., has recently been recognized as an emerging infectious disease worldwide. Despite its severity and global importance, knowledge about the molecular pathogenesis and virulence evolution of Leptospira spp. remains limited. Here we sequenced and analyzed 102 isolates representing global sources. A high genomic variability were observed among different Leptospira...

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PMID: 26833181
DOI: 10.1038/srep20020

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