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Article

miR-186 is decreased in aged brain and suppresses BACE1 expression.

Journal of neurochemistry - 1 May 2016

Kim Jaekwang, Yoon Hyejin, Chung Dah-Eun, Brown Jennifer L, Belmonte Krystal C, Kim Jungsu

Abstract excerpt

Accumulation of amyloid β (Aβ) in the brain is a key pathological hallmark of Alzheimer's disease (AD). Because aging is the most prominent risk factor for AD, understanding the molecular changes during aging is likely to provide critical insights into AD pathogenesis. However, studies on the role of miRNAs in aging and AD pathogenesis have only recently been initiated. Identifying miRNAs dysregulated by the...

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Identifiers

PMID: 26710318
DOI: 10.1111/jnc.13507
PMCID: PMC4837067

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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miR-186 is decreased in aged brain and suppresses BACE1 expression.PMID 26710318Read ↗

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