Article
Monkey electrophysiological and human psychophysical responses to mutants of the sweet protein brazzein: delineating brazzein sweetness.
Chemical senses - 1 Jul 2003
Jin Zheyuan, Danilova Vicktoria, Assadi-Porter Fariba M, Markley John L, Hellekant Göran
Abstract excerpt
Responses to brazzein, 25 brazzein mutants and two forms of monellin were studied in two types of experiments: electrophysiological recordings from chorda tympani S fibers of the rhesus monkey, Macaca mulatta, and psychophysical experiments. We found that different mutations at position 29 (changing Asp29 to Ala, Lys or Asn) made the molecule significantly sweeter than brazzein, while mutations at positions 30 or...
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