Article
Bypassing Mechanisms of Mitochondria‐Mediated Cancer Stem Cells Resistance to Chemo‐ and Radiotherapy
30 Nov 2015
Abstract excerpt
Cancer stem cells (CSCs) are highly resistant to conventional chemo- and radiotherapeutic regimes. Therefore, the multiple drug resistance (MDR) of cancer is most likely due to the resistance of CSCs. Such resistance can be attributed to some bypassing pathways including detoxification mechanisms of reactive oxygen and nitrogen species (RO/NS) formation or enhanced autophagy. Unlike in normal cells, where RO/NS...