Toward the most ideal case-control design with related and unrelated dogs in whole-exome sequencing studies.

Abstract excerpt

With the recent development of whole-exome sequencing enrichment designs for the dog, a novel tool for disease-association studies became available. The aim of disease-association studies is to identify one or a very limited number of putative causal variants or genes from the large pool of genetic variation. To maximize the efficiency of these studies and to provide some directions of what to expect, we...

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