Article
Lack of Siglec-7 expression identifies a dysfunctional natural killer cell subset associated with liver inflammation and fibrosis in chronic HCV infection.
Gut - 1 Dec 2016
Varchetta Stefania, Mele Dalila, Lombardi Andrea, Oliviero Barbara, Mantovani Stefania, Tinelli Carmine, Spreafico Marta, Prati Daniele, Ludovisi Serena, Ferraioli Giovanna, Filice Carlo, Aghemo Alessio, Lampertico Pietro, Facchetti Floriana, Bernuzzi Francesca, Invernizzi Pietro, Mondelli Mario U
Abstract excerpt
OBJECTIVE: Sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) is a natural killer (NK) cell inhibitory receptor associated with NK phenotypic and functional abnormalities in HIV-1 infection. We investigated the significance of NK-expressed and serum soluble Siglec-7 in relation to NK functional ability and parameters of liver necroinflammation and fibrosis in chronic HCV infection. DESIGN: NK-expressed...
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