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KONJAC1 and 2 Are Key Factors for GDP-Mannose Generation and Affect l-Ascorbic Acid and Glucomannan Biosynthesis in Arabidopsis.

The Plant cell - 1 Dec 2015

Sawake Shota, Tajima Noriaki, Mortimer Jenny C, Lao Jeemeng, Ishikawa Toshiki, Yu Xiaolan, Yamanashi Yukiko, Yoshimi Yoshihisa, Kawai-Yamada Maki, Dupree Paul, Tsumuraya Yoichi, Kotake Toshihisa

Abstract excerpt

Humans are unable to synthesize l-ascorbic acid (AsA), yet it is required as a cofactor in many critical biochemical reactions. The majority of human dietary AsA is obtained from plants. In Arabidopsis thaliana, a GDP-mannose pyrophosphorylase (GMPP), VITAMIN C DEFECTIVE1 (VTC1), catalyzes a rate-limiting step in AsA synthesis: the formation of GDP-Man. In this study, we identified two nucleotide sugar...

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Identifiers

PMID: 26672069
DOI: 10.1105/tpc.15.00379
PMCID: PMC4707449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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