Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study.

doi:10.1016/S2213-2600(15)00466-X

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Article

Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study.

The Lancet. Respiratory medicine - 1 Jan 2016

Pankhurst Louise J, Del Ojo Elias Carlos, Votintseva Antonina A, Walker Timothy M, Cole Kevin, Davies Jim, Fermont Jilles M, Gascoyne-Binzi Deborah M, Kohl Thomas A, Kong Clare, Lemaitre Nadine, Niemann Stefan, Paul John, Rogers Thomas R, Roycroft Emma, Smith E Grace, Supply Philip, Tang Patrick, Wilcox Mark H, Wordsworth Sarah, Wyllie David, Xu Li, Crook Derrick W

Abstract excerpt

BACKGROUND: Slow and cumbersome laboratory diagnostics for Mycobacterium tuberculosis complex (MTBC) risk delayed treatment and poor patient outcomes. Whole-genome sequencing (WGS) could potentially provide a rapid and comprehensive diagnostic solution. In this prospective study, we compare real-time WGS with routine MTBC diagnostic workflows. METHODS: We compared sequencing mycobacteria from all newly positive...

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PMID: 26669893
DOI: 10.1016/S2213-2600(15)00466-X
PMCID: PMC4698465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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