Article
Mechanistic Evaluation for Mixed-field Agglutination in the K562 Cell Study Model with Exon 3 Deletion of A1 Gene.
Annals of clinical and laboratory science - 1 Jan 2015
Chen Ding-Ping, Tseng Ching-Ping, Lin Chi-Jui, Wang Wei-Ting, Sun Chien-Feng
Abstract excerpt
In the case of blood type B3 with typical mixed-field agglutination of RBCs in the presence of anti-B or anti-AB antibody, a number of genetic alternations have been reported. It is well known that the IVS3+5G→A mutation in the B gene destroys the consensus of the splice donor site leading to exon 3 skipping during mRNA splicing. The lack of exon 3 likely causes a short stem region, producing an unstable B3...
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