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Article

Detection of Rare Drug Resistance Mutations by Digital PCR in a Human Influenza A Virus Model System and Clinical Samples.

Journal of clinical microbiology - 1 Feb 2016

Whale Alexandra S, Bushell Claire A, Grant Paul R, Cowen Simon, Gutierrez-Aguirre Ion, O'Sullivan Denise M, Žel Jana, Milavec Mojca, Foy Carole A, Nastouli Eleni, Garson Jeremy A, Huggett Jim F

Abstract excerpt

Digital PCR (dPCR) is being increasingly used for the quantification of sequence variations, including single nucleotide polymorphisms (SNPs), due to its high accuracy and precision in comparison with techniques such as quantitative PCR (qPCR) and melt curve analysis. To develop and evaluate dPCR for SNP detection using DNA, RNA, and clinical samples, an influenza virus model of resistance to oseltamivir...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 26659206
DOI: 10.1128/JCM.02611-15
PMCID: PMC4733194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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