Article
Association of MicroRNAs and YRNAs With Platelet Function.
Circulation research - 5 Feb 2016
Kaudewitz Dorothee, Skroblin Philipp, Bender Lukas H, Barwari Temo, Willeit Peter, Pechlaner Raimund, Sunderland Nicholas P, Willeit Karin, Morton Allison C, Armstrong Paul C, Chan Melissa V, Lu Ruifang, Yin Xiaoke, Gracio Filipe, Dudek Katarzyna, Langley Sarah R, Zampetaki Anna, de Rinaldis Emanuele, Ye Shu, Warner Timothy D, Saxena Alka, Kiechl Stefan, Storey Robert F, Mayr Manuel
Abstract excerpt
RATIONALE: Platelets shed microRNAs (miRNAs). Plasma miRNAs change on platelet inhibition. It is unclear whether plasma miRNA levels correlate with platelet function. OBJECTIVE: To link small RNAs to platelet reactivity. METHODS AND RESULTS: Next-generation sequencing of small RNAs in plasma revealed 2 peaks at 22 to 23 and 32 to 33 nucleotides corresponding to miRNAs and YRNAs, respectively. Among YRNAs,...
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